Dec. 1 (Sat.)
Plenary Lecture   16:15 - 17:00          Chair: Michael Davies
"Lipid peroxidation: New horizons"
   Etsuo Niki, Japan

Plenary Lecture   17:00 - 17:45          Chair: Toshikazu Yoshikawa
"What antioxidants are acting as antioxidants inside the body?"
   Angelo Azzi, United States of America


Dec. 2 (Sun.)
Plenary Lecture   9:15 - 10:00            Chair: Yuji Naito
"Flavanols, oxidants, and inflammation: search for biological connections"
   Cesar G. Fraga, United States of America

Plenary Lecture   10:00 - 10:45          Chair: Koji Uchida
"THE ROLE OF RADICALS IN PEPTIDE AND PROTEIN EVOLUTION"
   Christopher J. Easton, Australia

01.Detection of free radicals   11:00 - 12:30
                                         Chairs: Yasuteru Urano, Trevor A Mori
11:00 ~ 11:20
"Development of highly specific fluorescence probes for various reactive oxygen species and their application to real-time imaging of ROS production in living cells"
   Yasuteru Urano, Japan

11:20 - 11:40
"Biomarkers of Oxidative Damage: The Isoprostanes"
   Trevor A Mori, Australia

11:40 - 12:00
"Detection of ROS production in Helicobacter pylori CagA-expressed rat gastric epithelial cells."
   *Osamu Handa, Japan

12:00 - 12:15
"Detection, assessment and treatments of oxidative stress in biological systems"
    *Benjamin J Morrow, Australia

12:15 - 12:30
"ANGIOTENSIN II AND ENDOTHELIN-1 RELEASE 20-HETE FROM HUMAN NEUTROPHILS "
    ***I-Jung Tsai, Australia

P&G SKII Luncheon Seminar   12:40-13:40         Chair: Shinya Toyokuni
"Role of UV-induced Reactive Oxygen Species and Effects of ROS Scavengers in Skin"

"A New Approach for Visualization and Quantification of UVB-Induced Reactive Oxygen Species in Human Skin Equivalent Model"
   Hiroyuki Yasui, Japan

"Effects of a Natural ROS Scavenger SFF in Skin using a New Approach"
   Akira Date, Japan

02.Nitric oxide   14:00 - 15:30
                                         Chairs: Takaaki Akaike, Steven Bottle
14:00 - 14:20
"A new second messenger, 8-nitroguanosine 3',5'-cyclic monophosphate involved in NO-induced signal transduction via a unique post-translational modification, protein S-guanylation"
    Takaaki Akaike, Japan

14:20 - 14:40
"Dual Action Antioxidants"
    Steven E. Bottle, Australia

14:40 - 15:00
"The expression of nitric oxide (NO)-modified proteins in Helicobacter pylori-associated inflamed gastric mucosa"
    *Tomohisa Takagi, Japan

15:00 - 15:15
"Nitric oxide and nitroxides can act as efficient scavengers of protein-derived free radicals"
    *Magdalena A. Lam, Australia

15:15 - 15:30
"Concomitant administration of carvedilol attenuates nitrate tolerance via preventing superoxide production and depletion of Cytochrome P450"
    *Atsushi Nakahira, Japan

03.Antioxidants   15:45 - 17:15
                                         Chairs: Yuji Naito, Shane R Thomas
15:45 - 16:05
"The antioxidant actions of zinc."
    Patricia I. Oteiza, United States of America

16:05 - 16:25
"The flavonoid quercetin and some of its major human metabolites inhibit stimulated neutrophil modification of LDL via inhibition of myeloperoxidase"
    Julie M Proudfoot, Australia

16:25 - 16:45
"Alpha-tocopherol Improves Diabetic Complications via the Reduction of Mitochondrial Reactive Oxygen Species in Type II Diabetic Rats"
    Yukiko Minamiyama, Japan

16:45 - 17:00
"Effects of α-tocopherol and Mixed Tocopherol Supplementation on Markers of Oxidative Stress and Inflammation in Type 2 Diabetes"
    *Jason HY Wu, Australia

17:00 - 17:15
"THE EFFECT OF α-LINOLENIC ACID ON MARKERS OF LIPID PEROXIDATION"
    Anne E Barden, Australia


Dec. 3 (Mon.)
04.Protein/proteomics    9:15 - 10:45
                                         Chairs: Koji Uchida, David I Pattison
9:15 - 9:35
"Covalent modification of proteins by lipid peroxidation products: From biomarker to etiology"
    Koji Uchida, Japan

9:35 - 9:55
"Protein and Plasma Targets of Myeloperoxidase Derived Oxidants: A Kinetic Modelling Approach"
    David I. Pattison, Australia

9:55 - 10:15
"Analysis of modified apolipoprotein B-100 structures formed in oxidized low-density lipoprotein using LC-MS/MS."
    Takashi Obama, Japan

10:15 - 10:30
"Detection, characterisation and quantitation of side-chain versus backbone hydroperoxides on amino acids, peptides and proteins"
    *Philip E. Morgan, Australia

10:30 - 10:45
"1,4- and 1,5-Hydrogen Atom Transfer in Amino Acid and Peptide Radicals "
    *Satish Chand, Australia

05.Redox signaling   11:00 - 12:30
                                         Chairs: Hiroshi Masutani, Alfons Lawen
11:00 - 11:20
"Redox regulation of cell survival and metabolism by thioredoxin and TBP-2"
    Hiroshi Masutani, Japan

11:20 - 11:40
"Characterisation of an ascorbate-stimulated ferricyanide reductase activity in K562 cells and its potential involvement in cellular iron uptake"
    Alfons Lawen, Australia

11:40 - 12:00
"CONTROLLING INFLAMMATORY GENE EXPRESSION BY PHARMACOLOGICAL REPRESSION OF MITOCHONDRIAL FREE RADICAL ACCUMULATION"
    *Reagan M Jarvis, New Zealand

12:00 - 12:15
"Peroxiredoxin II provides protection against neutrophil-derived oxidants in human erythrocytes"
    ***Melissa M. Stacey, New Zealand

12:15 - 12:30
"The Iron-Regulated Metastasis Suppressor, Ndrg-1: Identification of Novel Cell-Specific Targets that Include the Energy Currency Modulator, Thiamine Triphosphatase."
    ***Zaklina Kovacevic, Australia

06.Apoptosis   14:00 - 15:20
                                         Chairs: Hideyuki J Majima, Jiri Neuzil
14:00 - 14:20
"Mitochondrial DNA Damaged Cells Increase Generation of ROS from Mitochondria and Are Susceptible to Apoptosis"
    Hideyuki J Majima, Japan

14:20 - 14:40
"VITAMIN E ANALOGUES SELECTIVELY INHIBIT ANGIOGENESIS: THE ROLE OF OXIDATIVE STRESS"
    Jiri Neuzil, Australia

14:40 - 15:00
"Rapid and transient intracellular oxidative stress due to novel macrosphelides trigger apoptosis via Fas/caspase-8-dependent pathway in human lymphoma U937 cells"
    Kanwal Ahmed, Japan

15:00 - 15:20
"Hypothiocyanous acid is a potent inducer of apoptosis and thiol depletion in J774A.1 cells"
    ***Mitchell M. Lloyd, Australia

Plenary Lecture   15:40 - 16:40          Chair: Shinya Toyokuni
"Engulfment of Apoptotic Cells"
    Shigekazu Nagata, Japan

Poster Session   17:00 - 18:30



Dec. 4 (Tue.)
07.Atherosclerosis/reperfusion    9:15 - 10:30
                                         Chairs: Noriko Noguchi, Roland Stocker
9:15 - 9:35
"Protective roles of Nrf2 in atherogenic gene expression of endothelial cell upon exposure to shear stress"
    Noriko Noguchi, Japan

9:35 - 9:55
"Antioxidant inducers of heme oxygenase-1: A new class of anti-atherosclerotic agents?"
    Roland Stocker, Australia

9:55 - 10:15
"OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION"
    Shane R Thomas, Australia

10:15 - 10:30
"The plasma oxidized LDL levels increased prior to atherosclerotic lesion development in apoE-knockout mice."
    Rina Kato, Japan

08.Cancer    11:00 - 12:30
                                         Chairs: Shinya Toyokuni, Des Richardson
11:00 - 11:20
"Chronic oxidative stress as a cause of genomic amplification and deletion"
    Shinya Toyokuni, Japan

11:20 - 11:40
"THE MELANOMA TUMOUR ANTIGEN, P97 (MELANOTRANSFERRIN): FROM IRON METABOLISM TO TUMOURIGENESIS"
    Des Richardson, Australia

11:40 - 12:00
"Prevention of inflammation-mediated malignant conversion of tumor cells by orally available superoxide dismutase"
    Futoshi Okada, Japan

12:00 - 12:15
"alpha-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in the mitochondrial respiratory complex II"
    *Lanfeng Dong, Australia

12:15 - 12:30
"DEVELOPMENT OF NOVEL AND SELECTIVE ANTI-TUMOUR AGENTS FOR THE TREATMENT OF CANCER"
    ***Yu Yu, Australia

09.Neurodegeneration and autoimmune diseases    13:30 - 14:50
                                         Chairs: Junichi Fujii, Paul K Witting
13:30 - 13:50
"Oxidative Stress-Induced Autoantibody Production against Erythrocytes in Mice"
    Junichi Fujii, Japan

13:50 - 14:10
"NEUROGLOBIN OVER-EXPRESSION IN NEURONAL CELLS PROTECTS AGAINST HYDROGEN PEROXIDE INSULT"
    Paul K. Witting, Australia

14:10 - 14:30
"Mitochondrial NADP+-dependent isocitrate dehydrogenase regulates ionizing radiation-induced apoptosis"
    Jeen-Woo Park, Republic of Korea

14:30 - 14:50
"Iron Metabolism in Friedreich's Ataxia: Disruption of Frataxin Expression In Vivo Increases Transferrin Receptor-1 Mediated Iron Uptake Targeted to the Mitochondrion"
    **Megan Whitnall, Australia

Young investigator's session   15:10 - 17:10          Chairs: Kevin D Croft, Shinya Toyokuni
15:10 - 15:25
"Involvement of oxidative stress in indomethacin-induced apoptosis of small intestinal epithelial cells"
    *Tatsushi Omatsu, Japan

15:25 - 15:40
"MELANOMA TUMOR ANTIGEN P97 (MELANOTRANSFERRIN): A ROLE IN MELANOMA CELL PROLIFERATION AND TUMOURIGENESIS"
    *Yohan Suryo Rahmanto, Australia

15:40 - 15:55
"Iron chelation by clinically relevant anthracyclines: alteration in expression of iron-regulated genes and atypical changes in intracellular iron distribution and trafficking "
    *Xiangcong Xu, Australia

15:55 - 16:10
"Synthesis of Peptides Incorporating Non-proteinogenic Amino Acids Produced Through Radical Functionalisation of Proteinogenic Analogues"
   *Zachary I. Watts, Australia

16:10 - 16:25
"Roles of intracellular superoxide (generation) in chemical enhancement of heat-induced apoptosis"
    *Da-yong Yu, Japan

16:25 - 16:40
"Analysis of chromosomal alterations in oxidative stress-induced rat renal carcinomas using array-based CGH"
    *Shinya Akatsuka, Japan

16:40 - 16:55
"Determination of in- vitro antioxidant activity by different methods of some Sri Lankan Medicinal plants used in Ayurveda as cardio-protective agents."
    *D.N. Ranatunga, Democratic Socialist Republic of Sri Lanka

16:55 - 17:10
"Redox regulation of cyclin D1 by Thioredoxin"
    *Michika Mochizuki, Japan

Dec. 5 (Wed.)
10.Inflammatory diseases    9:15 - 10:40
                                         Chairs: Eisuke F Sato, Kevin D Croft
9:15 - 9:35
"Oxidative Stress during the Ovulatory Process"
    Eisuke F. Sato, Japan

9:35 - 9:55
"Dietary antioxidants, oxidative stress and inflammation: results from human intervention studies"
    Kevin D Croft, Australia

9:55 - 10:10
"Covalent modification of protein thiols by serotonin oxidation products formed by the catalytic action of myeloperoxidase"
    Yoji Kato, New Zealand

10:10 - 10:25
"Thioredoxin-1 prevents cigarette smoke-induced emphysema in mice."
    Yuma Hoshino, Japan

10:25 - 10:40
"Metabolic transformation has profound effect on anti-inflammatory activity of flavonoids: Lack of association between antioxidant and lipoxygenase inhibitory activity in quercetin"
    **Wai Mun Loke, Australia

11.UV/X-irradiation    10:55 - 12:15
                                         Chairs: Kazumori Anzai, Michael J Davies
10:55 - 11:15
"Generation of Free Radicals by X-irradiation and Protection of Radiation-injuries by Antioxidants"
    Kazunori Anzai, Japan

11:15 - 11:35
"Formation and cellular consequences of peroxide formation on proteins"
    Michael J. Davies, Australia

11:35 - 11:55
"Suppressive effect of ascorbic acid derivatives against UVA-induced reactive oxygen species generation in the skin of hairless mice"
    Akemi Komori, Japan

11:55 - 12:15
"Biomedical Application of Electron Spin Resonance (ESR) Spectroscopy -Assessment of Antioxidant Property of Drugs or Foods- "
    Masaichi-Chang-il Lee, Japan